Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres

Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres.

Flaviviruses assemble as fusion-incompetent immature particles and subsequently undergo conformational change leading to release of infectious virions. Flavivirus infections also produce combined 'mosaic' particles. Here, using cryo-electron tomography, we report that mosaic particles of dengue virus type 2 had glycoproteins organized into two regions of mature and immature structure. Furthermo...

Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centers

Social Support or Organizational Support: Which One Is More Predictive of Job Burnout in workers?

  Introduction: Social and organizational supports are effective factors closely related to job burnout and Due to the limited studies in this area on Iranian workers, this study aims to determine the predictability of social support and organizational support in  job burnout for workers in Yazd. Methods: This cross-sectional study was carried out among 200 textile workers in Yazd through str...

Cutting Your Teeth: Learning from Rare (One or More) Experiences

In this paper, we explore learning-by-doing in a unique and important setting not previously exploredthe context of one or more complex experiences encountered in novel circumstances. We explore characteristics that lead to learning from small sets of prior experiences. We use data from survey responses of 2,111 entrepreneurs to examine performance of startup firms as a measure of outcomes prod...

Influenza: one or two more questions

Received wisdom has it that pathogens are not generally lethal to the hosts they normally infect, because they could not survive if they were. Pathogenicity thus becomes adapted to a level at which the host survives to become reinfected (or to produce young that become infected). The most notable example of such adaptation is in the herpesviruses, which have evolved a quite extraordinary repert...